| | Runs | playerId | seasonId | clubId | matchId | Runs | Player | Team | Season | Grade | Round | Inns | Opponent |
| 1 | 100 | 1077367 | 155 | 27694 | 3839889 | 100* | Prabhav Mishra | Yarra-United | 2021/2022 | A Grade | 2 | 1 | Youlden Parkville |
| 2 | 84 | 366419 | 155 | 424 | 3839888 | 84 | Sean B Wilson | Parkville District | 2021/2022 | A Grade | 2 | 1 | Indigos |
| 3 | 84 | 1653629 | 155 | 482 | 3839894 | 84 | Dhruv Dave | National | 2021/2022 | A Grade | 3 | 1 | Flemington |
| 4 | 82 | 576944 | 155 | 1081 | 3839890 | 82* | Bradley Fawcus | Flemington | 2021/2022 | A Grade | 2 | 1 | Emerald Hill |
| 5 | 73 | 1026654 | 155 | 424 | 3839888 | 73* | Chris B Thomson | Parkville District | 2021/2022 | A Grade | 2 | 1 | Indigos |
| 6 | 67 | 1096755 | 155 | 101 | 3839887 | 67 | Sam Chapman | South Yarra | 2021/2022 | A Grade | 2 | 1 | National |
| 7 | 67 | 382579 | 155 | 437 | 3839889 | 67 | Gus Coverdale | Youlden Parkville | 2021/2022 | A Grade | 2 | 1 | Yarra-United |
| 8 | 60 | 330149 | 155 | 424 | 3839891 | 60 | Nathan Green | Parkville District | 2021/2022 | A Grade | 3 | 1 | Yarra-United |
| 9 | 59 | 1154264 | 155 | 11980 | 3839888 | 59* | Phanindra V Penumetcha | Indigos | 2021/2022 | A Grade | 2 | 1 | Parkville District |
| 10 | 57 | 56651 | 155 | 2071 | 3839892 | 57 | Matt Corstorphin | Emerald Hill | 2021/2022 | A Grade | 3 | 1 | Indigos |
| 11 | 57 | 1653629 | 155 | 482 | 3839887 | 57 | Dhruv Dave | National | 2021/2022 | A Grade | 2 | 1 | South Yarra |
| 12 | 54 | 819683 | 155 | 2071 | 3839892 | 54 | Hussain Attar | Emerald Hill | 2021/2022 | A Grade | 3 | 1 | Indigos |
| 13 | 50 | 1061711 | 155 | 11980 | 3839888 | 50 | Vamsidhar R Soma | Indigos | 2021/2022 | A Grade | 2 | 1 | Parkville District |
Note: Qualification levels for this report are 50 and 100 runs.
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